Journal article
Non-dioxin-like polychlorinated biphenyls and risk of endometriosis
Environmental health perspectives, v 118(9), pp 1280-1285
Sep 2010
PMID: 20423815
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Endometriosis, a gynecologic disorder affecting 8-10% of reproductive-age women in the United States, is defined as the presence of endometrial tissue outside the uterus and is linked to pelvic pain and infertility. Environmental contaminants, including polychlorinated biphenyls (PCBs), are hypothesized to contribute to endometriosis risk through effects on steroid hormones.
We evaluated serum concentrations of certain noncoplanar PCBs, which have no or only weak dioxin-like properties, as risk factors for endometriosis.
In a case-control study of Group Health enrollees in western Washington State, 20 PCB congeners were measured in serum from surgically confirmed endometriosis cases that were newly diagnosed between 1996 and 2001 (n = 251) and from female controls matched for age and reference year (n = 538).
Summed and estrogenic PCB concentrations were not associated with endometriosis risk [summed: odds ratio (OR) = 1.3; 95% confidence interval (CI), 0.8-2.2; estrogenic: OR = 1.1; 95% CI, 0.8-1.4]. Although several congener-specific ORs were statistically above or below the null (PCB 170: third quartile vs. lowest: OR = 0.5; 95% CI, 0.3-0.9; PCB 196: third quartile vs. lowest: OR = 0.4; 95% CI, 0.2-0.7; PCB 201: second vs. lowest: OR = 0.5; 95% CI, 0.3-0.8; third quartile vs. lowest: OR = 0.4; 95% CI, 0.2-0.7), there were no overall consistent patterns of endometriosis risk.
Taken in context with other North American studies, our findings suggest that noncoplanar PCB concentrations consistent within the range of exposure currently observed in western Washington State do not contribute meaningfully to endometriosis risk.
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Details
- Title
- Non-dioxin-like polychlorinated biphenyls and risk of endometriosis
- Creators
- Britton Trabert - University of WashingtonAnneclaire J De Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaStephen M Schwartz - University of WashingtonUlrike Peters - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaDelia Scholes - Group Health CooperativeDana B Barr - Centers for Disease Control and PreventionVictoria L Holt - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
- Publication Details
- Environmental health perspectives, v 118(9), pp 1280-1285
- Grant note
- R01HD033792 / NICHD NIH HHS T32HD052462 / NICHD NIH HHS T32 HD052462 / NICHD NIH HHS R01 HD033792 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000281621500016
- Scopus ID
- 2-s2.0-77956815829
- Other Identifier
- 991020100058404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology