Journal article
Non-genetic engineering of cells for drug delivery and cell-based therapy
Advanced drug delivery reviews, v 91
30 Aug 2015
PMID: 25543006
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cell-based therapy is a promising modality to address many unmet medical needs. In addition to genetic engineering, material-based, biochemical, and physical science-based approaches have emerged as novel approaches to modify cells. Non-genetic engineering of cells has been applied in delivering therapeutics to tissues, homing of cells to the bone marrow or inflammatory tissues, cancer imaging, immunotherapy, and remotely controlling cellular functions. This new strategy has unique advantages in disease therapy and is complementary to existing gene-based cell engineering approaches. A better understanding of cellular systems and different engineering methods will allow us to better exploit engineered cells in biomedicine. Here, we review non-genetic cell engineering techniques and applications of engineered cells, discuss the pros and cons of different methods, and provide our perspectives on future research directions. (C) 2014 Elsevier B.V. All rights reserved.
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Details
- Title
- Non-genetic engineering of cells for drug delivery and cell-based therapy
- Creators
- Qun Wang - Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.Hao Cheng - Drexel UniversityHaisheng Peng - Iowa State UniversityHao Zhou - Drexel UniversityPeter Y. Li - Drexel UniversityRobert Langer - Harvard–MIT Division of Health Sciences and Technology
- Publication Details
- Advanced drug delivery reviews, v 91
- Publisher
- Elsevier
- Number of pages
- 16
- Grant note
- Controlled Release Society Foundation Drexel University Clinical and Translational Research Institute (CTRI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000361929400010
- Scopus ID
- 2-s2.0-84940954525
- Other Identifier
- 991019168682504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy