Journal article
Non-human Primate Model to Study the Role of Serum and Vaginal IgA in Acquisition of Infection
AIDS research and human retroviruses, Vol.29(11)
01 Nov 2013
Abstract
Background: Following the success of the RV144 trial, correlates analysis showed a possible correlation between serum IgA titers and lack of vaccine effectiveness. This data is in contrast to the concept that a protective HIV vaccine will need to induce strong IgA induction to prevent mucosal. To address the role of serum and vaginal IgA in HIV acquisition we utilized an adjuvanted DNA vaccine previously shown to drive IgA induction in a nonhuman primate vaginal challenge model.
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Details
- Title
- Non-human Primate Model to Study the Role of Serum and Vaginal IgA in Acquisition of Infection
- Creators
- N HutnickM KutzlerZ MoldoveanuM HunterM WiseJ YanA SylvesterB PaharD MylesA KhanD MontefioriN SardesaiJ MesteckyP MarxD Weiner
- Publication Details
- AIDS research and human retroviruses, Vol.29(11)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Identifiers
- 991019170597104721