Journal article
Non-lymphoma hematological malignancies in systemic lupus erythematosus
Oncology, v 85(4), pp 235-240
01 Jan 2013
PMID: 24107608
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE).
A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers.
In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks).
In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation.
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Details
- Title
- Non-lymphoma hematological malignancies in systemic lupus erythematosus
- Creators
- Mary Lu - McGill University Health CentreSasha Bernatsky - McGill UniversityRosalind Ramsey-Goldman - Center for RheumatologyMichelle Petri - Johns Hopkins UniversitySusan Manzi - Western Pennsylvania HospitalMurray B Urowitz - Toronto Western HospitalDafna Gladman - Toronto Western HospitalPaul R Fortin - Université LavalEllen M Ginzler - SUNY Downstate Health Sciences UniversityEdward Yelin - Center for RheumatologySang-Cheol BaeDaniel J Wallace - University of California, Los AngelesSoren JacobsenMary Anne Dooley - University of North Carolina at Chapel HillChristine A Peschken - University of ManitobaGraciela S Alarcón - University of Alabama at BirminghamOla Nived - Lund UniversityLena Gottesman - SUNY Downstate Health Sciences UniversityLindsey A Criswell - University of California, San FranciscoGunnar Sturfelt - Lund UniversityLene Dreyer - University of CopenhagenJennifer L Lee - McGill UniversityAnn E Clarke - McGill University
- Publication Details
- Oncology, v 85(4), pp 235-240
- Grant note
- P60 AR053308 / NIAMS NIH HHS UL1 TR000150 / NCATS NIH HHS R03 CA173822 / NCI NIH HHS R03 CA128052 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000326934400007
- Scopus ID
- 2-s2.0-84885036201
- Other Identifier
- 991021934005004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology