Journal article
Non-muscle myosin II and the plasticity of 3D cell migration
Frontiers in cell and developmental biology, Vol.10, pp.1047256-1047256
10 Nov 2022
PMID: 36438570
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Confined cells migrating through 3D environments are also constrained by the laws of physics, meaning for every action there must be an equal and opposite reaction for cells to achieve motion. Fascinatingly, there are several distinct molecular mechanisms that cells can use to move, and this is reflected in the diverse ways non-muscle myosin II (NMII) can generate the mechanical forces necessary to sustain 3D cell migration. This review summarizes the unique modes of 3D migration, as well as how NMII activity is regulated and localized within each of these different modes. In addition, we highlight tropomyosins and septins as two protein families that likely have more secrets to reveal about how NMII activity is governed during 3D cell migration. Together, this information suggests that investigating the mechanisms controlling NMII activity will be helpful in understanding how a single cell transitions between distinct modes of 3D migration in response to the physical environment.
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Details
- Title
- Non-muscle myosin II and the plasticity of 3D cell migration
- Creators
- James M. Cowan - Drexel UniversityJacob J. Duggan - Drexel Univ, Dept Biol, Philadelphia, PA 19104 USABreanne R. Hewitt - Drexel Univ, Dept Biol, Philadelphia, PA 19104 USARyan J. Petrie - Drexel Univ, Dept Biol, Philadelphia, PA 19104 USA
- Publication Details
- Frontiers in cell and developmental biology, Vol.10, pp.1047256-1047256
- Publisher
- Frontiers Media Sa
- Number of pages
- 15
- Grant note
- National Institute of General Medical Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Identifiers
- 991020100075704721
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- Web of Science research areas
- Cell Biology
- Developmental Biology