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Journal article
Non-thermal atmospheric plasma treatment of onychomycosis in an in vitro human nail model
Mycoses, v 63(2), pp 225-232
Feb 2020
PMID: 31677288
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Onychomycosis affects almost 6% of the world population. Topical azoles and systemic antifungal agents are of low efficacy and can have undesirable side effects. An effective, non-invasive therapy for onychomycosis is an unmet clinical need.
Determine the efficacy threshold of non-thermal atmospheric plasma (NTAP) to treat onychomycosis in an in vitro model.
A novel toe/nail-plate model using cadaver nails and agarose media inoculated with Candida albicans was exposed to a range of NTAP doses.
Direct exposure of C albicans and Trichophyton mentagrophytes to 12 minutes of NTAP results in complete killing at doses of 39 and 15 kPulses, respectively. Onset of reduced viability of C albicans to NTAP treatment through the nail plate occurs at 64 kPulses with 10× and 100× reduction at 212 and 550 kPulses, respectively.
NTAP is an effective, non-invasive therapeutic approach to onychomycosis that should be evaluated in a clinical setting.
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Details
- Title
- Non-thermal atmospheric plasma treatment of onychomycosis in an in vitro human nail model
- Creators
- Jeffry M Bulson - MOE Medical Devices LLC, Valhalla, NY, USA.Dionysios Liveris - New York Medical CollegeIrina Derkatch - MOE Medical Devices LLC, Valhalla, NY, USA.Gary Friedman - Drexel UniversityJan Geliebter - MOE Medical Devices LLC, Valhalla, NY, USA.Sin Park - MOE Medical Devices LLC, Valhalla, NY, USA.Sarnath Singh - New York Medical CollegeMarc Zemel - MOE Medical Devices LLC, Valhalla, NY, USA.Raj K Tiwari - New York Medical College
- Publication Details
- Mycoses, v 63(2), pp 225-232
- Publisher
- Wiley
- Grant note
- MOE Medical Devices, LLC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering
- Web of Science ID
- WOS:000502560900001
- Scopus ID
- 2-s2.0-85076737826
- Other Identifier
- 991019196449104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology
- Mycology