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Accepted (AM)CC BY-NC-ND V4.0, Open
Journal article
Non-thermal plasma-induced immunogenic cell death in cancer
Journal of physics. D, Applied physics, v 52(42), p423001
16 Oct 2019
PMID: 31485083
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent advances in biomedical research in cancer immunotherapy have identified the use of an oxidative stress-based approach to treat cancers, which works by inducing immunogenic cell death (ICD) in cancer cells. Since the anti-cancer effects of non-thermal plasma (NTP) are largely attributed to the reactive oxygen and nitrogen species that are delivered to and generated inside the target cancer cells, it is reasonable to postulate that NTP would be an effective modality for ICD induction. NTP treatment of tumors has been shown to destroy cancer cells rapidly and, under specific treatment regimens, this leads to systemic tumor-specific immunity. The translational benefit of NTP for treatment of cancer relies on its ability to enhance the interactions between NTP-exposed tumor cells and local immune cells which initiates subsequent protective immune responses. This review discusses results from recent investigations of NTP application to induce ICD in cancer cells. With further optimization of clinical devices and treatment protocols, NTP can become an essential part of the therapeutic armament against cancer.
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Details
- Title
- Non-thermal plasma-induced immunogenic cell death in cancer
- Creators
- Marian Khalili - Drexel UniversityLynsey Daniels - Drexel UniversityAbraham Lin - University of AntwerpFred C Krebs - Drexel UniversityAdam E Snook - Thomas Jefferson UniversitySander Bekeschus - Leibniz Institute for Plasma Science and TechnologyWilbur B Bowne - Drexel UniversityVandana Miller - Leibniz Institute for Plasma Science and Technology
- Publication Details
- Journal of physics. D, Applied physics, v 52(42), p423001
- Publisher
- IOP Publishing
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000479103100001
- Scopus ID
- 2-s2.0-85071493618
- Other Identifier
- 991019168443604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physics, Applied