Journal article
Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors
Oncoimmunology, v 7(9), pp e1484978-e1484978
02 Sep 2018
PMID: 30228954
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Immunogenic cell death is characterized by the emission of danger signals that facilitate activation of an adaptive immune response against dead-cell antigens. In the case of cancer therapy, tumor cells undergoing immunogenic death promote cancer-specific immunity. Identification, characterization, and optimization of stimuli that induce immunogenic cancer cell death has tremendous potential to improve the outcomes of cancer therapy. In this study, we show that non-thermal, atmospheric pressure plasma can be operated to induce immunogenic cell death in an animal model of colorectal cancer. In vitro, plasma treatment of CT26 colorectal cancer cells induced the release of classic danger signals. Treated cells were used to create a whole-cell vaccine which elicited protective immunity in the CT26 tumor mouse model. Moreover, plasma treatment of subcutaneous tumors elicited emission of danger signals and recruitment of antigen presenting cells into tumors. An increase in T cell responses targeting the colorectal cancer-specific antigen guanylyl cyclase C (GUCY2C) were also observed. This study provides the first evidence that non-thermal plasma is a bone fide inducer of immunogenic cell death and highlights its potential for clinical translation for cancer immunotherapy.
Metrics
Details
- Title
- Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors
- Creators
- Abraham G. Lin - C. & J. Nyheim Plasma Institute, Drexel University, Camden, NJ, USA.Bo Xiang - University of WashingtonDante J. Merlino - Thomas Jefferson UniversityTrevor R. Baybutt - Thomas Jefferson UniversityJoya Sahu - Thomas Jefferson University HospitalAlexander Fridman - Drexel UniversityAdam E. Snook - Thomas Jefferson UniversityVandana Miller - C. & J. Nyheim Plasma Institute, Drexel University, Camden, NJ, USA.
- Publication Details
- Oncoimmunology, v 7(9), pp e1484978-e1484978
- Publisher
- Taylor & Francis
- Grant note
- F30 DK103492 / NIH to D. Merlino P30 CA56036 / Kimmel Cancer Center of Thomas Jefferson University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000443993100030
- Scopus ID
- 2-s2.0-85050673539
- Other Identifier
- 991019169801604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Oncology