Journal article
Nonabsorbable radioactive material in the treatment of carcinomas by local injections
Cancer, v 61(5), pp 931-940
01 Mar 1988
PMID: 3257407
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nonabsorbable radioactive material was used in treating malignant lesions by local injection. One hundred thirty‐five Lewis Wistar rats were inoculated subcutaneously with tumor cells. After 7 days, the rats grew tumors of approximately 1 × 1 × 1 cm at the injection site. The rats then were divided into two groups; 50% were kept as a contol group while the other 50% received single injections of 1 mCi yttrium 90 (90Y) microspheres directly into the center of the tumor. This study shows a significant reduction of the tumor growth rate in treated animals. Tumor sizes after 4 days averaged 1.31 ml in the treated rats and 9.74 ml in the control group. Excluding animals that had complete regression of the tumor, treated rats lived an average of 30.8 days from the day of treatment compared with the control rats, which lived an average of 17.4 days. Pathology examinations showed no effects from injected radioactive materials in the liver, bone marrow or the kidney. Examination of the injected area after 6 months showed that microspheres remained locally and that the tumor was replaced with collagen tissue.
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Details
- Title
- Nonabsorbable radioactive material in the treatment of carcinomas by local injections
- Creators
- Karim B. Nakhgevany - Drexel UniversityJalal Mobini - Drexel UniversityJames G. Bassett - Drexel UniversityElizabeth Miller - University of PennsylvaniaEmily Nicole Miller - Psychology
- Publication Details
- Cancer, v 61(5), pp 931-940
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:A1988M182000012
- Scopus ID
- 2-s2.0-0023864271
- Other Identifier
- 991019183961604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology