Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Nonalcoholic fatty liver disease across ethno-racial groups: Do Asian-American adults represent a new at-risk population?
Journal of gastroenterology and hepatology, v 26(3), pp 501-509
Mar 2011
PMID: 21332546
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Aim: Nonalcoholic fatty liver disease (NAFLD) is increasingly common worldwide. We explored clinical, laboratory, and histological features of NAFLD as well as risk factors for histologically advanced disease among under-represented ethno-racial groups.
Methods: Patient records from one NAFLD clinic in California from 1998-2008 were reviewed. Biopsies were graded using Brunt criteria by a hepatopathologist blinded to clinical data. We used multivariate logistic regression to assess associations between ethno-racial group and histological severity of NAFLD, while controlling for other factors.
Results: We identified 90 biopsy-proven cases of NAFLD. Mean age was 49 years (standard deviation [SD] = 11.6), and half were female. 52% of patients were Caucasian, 20% Latino-American, 18% Asian-American, and 10% Middle Eastern-American. There were significant differences among groups with respect to age, weight, body mass index (BMI), and grade of hepatic steatosis (all P < 0.05). In multivariate analysis, older age was associated with severe (Brunt >= 2) inflammation (odds ratio [OR] 1.1, P = 0.002) and severe (Brunt > 3) fibrosis (OR 1.2, P = 0.001), diabetes was associated with severe inflammation (OR 3.18, P = 0.07) and severe fibrosis (OR 8.81, P = 0.002), and increased BMI was associated with severe fibrosis (OR 2.43, P = 0.07). Additionally, compared to Caucasians, Asian-Americans showed a trend toward an association with severe (Brunt > 2) steatosis (OR 3.83, P = 0.08) and severe inflammation (OR 5.42, P = 0.06).
Conclusions: The findings from this ethno-racially diverse clinic-based cohort are consistent with prior studies and also suggest that Asian-Americans may be at risk for advanced NAFLD. This may have implications for the prevention, evaluation, and treatment of patients with NAFLD that merit further study.
Metrics
Details
- Title
- Nonalcoholic fatty liver disease across ethno-racial groups: Do Asian-American adults represent a new at-risk population?
- Creators
- James H. Tabibian - Johns Hopkins UniversityMariana Lazo - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USAFrancisco A. Durazo - Dumont UCLA Liver Transplant Ctr, Los Angeles, CA USAHsin-Chieh Yeh - Johns Hopkins UniversityMyron J. Tong - Dumont UCLA Liver Transplant Ctr, Los Angeles, CA USAJeanne M. Clark - Johns Hopkins University
- Publication Details
- Journal of gastroenterology and hepatology, v 26(3), pp 501-509
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- P30DK079637 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Johns Hopkins Osler Fund
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000287454100015
- Scopus ID
- 2-s2.0-79951624285
- Other Identifier
- 991020550345104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology