Journal article
Noninvasive Estimation of Dynamic Pressures In Vitro and In Vivo Using the Subharmonic Response From Microbubbles
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, v 58(10), pp 2056-2066
01 Oct 2011
PMID: 21989870
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to develop and validate a noninvasive pressure estimation technique based on subharmonic emissions from a commercially available ultrasound contrast agent and scanner, unlike other studies that have either adopted a single-element transducer approach and/or use of in-house contrast agents. Ambient pressures were varied in a closed-loop flow system between 0 and 120 mmHg and were recorded by a solid-state pressure catheter as the reference standard. Simultaneously, the ultrasound scanner was operated in pulse inversion mode transmitting at 2.5 MHz, and the unprocessed RF data were captured at different incident acoustic pressures (from 76 to 897 kPa). The subharmonic data for each pulse were extracted using band-pass filtering with averaging, and subsequently processed to eliminate noise. The incident acoustic pressure most sensitive to ambient pressure fluctuations was determined, and then the ambient pressure was tracked over 20 s. In vivo validation of this technique was performed in the left ventricle (LV) of 2 canines. In vitro, the subharmonic signal could track ambient pressure values with r(2) = 0.922 (p < 0.001), whereas in vivo, the subharmonic signal tracked the LV pressures with r(2) > 0.790 (p < 0.001) showing a maximum error of 2.84 mmHg compared with the reference standard. In conclusion, a subharmonic ultrasound-based pressure estimation technique, which can accurately track left ventricular pressures, has been established.
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Details
- Title
- Noninvasive Estimation of Dynamic Pressures In Vitro and In Vivo Using the Subharmonic Response From Microbubbles
- Creators
- Jaydev K. Dave - Thomas Jefferson UniversityValgerdur G. Halldorsdottir - Thomas Jefferson UniversityJohn R. Eisenbrey - Thomas Jefferson UniversityJi-Bin Liu - Thomas Jefferson UniversityMaureen E. McDonald - Thomas Jefferson UniversityKris Dickie - College Station Medical CenterCorina Leung - College Station Medical CenterFlemming Forsberg - Thomas Jefferson University
- Publication Details
- IEEE transactions on ultrasonics, ferroelectrics, and frequency control, v 58(10), pp 2056-2066
- Publisher
- IEEE
- Number of pages
- 11
- Grant note
- RC1DK087365 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R21HL081892 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 0655441U / AHA; American Heart Association W81XWH-08-1-0503 / U.S. Army Medical Research Material Command; U.S. Army Medical Research & Materiel Command (USAMRMC) R21 HL081892; RC1 DK087365 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000297007300005
- Scopus ID
- 2-s2.0-80054073835
- Other Identifier
- 991019350675304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Acoustics
- Engineering, Electrical & Electronic