Journal article
Noninvasive Thermal Evaluation of Ventriculoperitoneal Shunt Patency and Cerebrospinal Fluid Flow Using a Flow Enhancing Device
Neurosurgery, v 85(2), pp 240-249
01 Aug 2019
PMID: 29917093
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While a noninvasive flow determination would be desirable in the diagnosis of cerebrospinal fluid shunt malfunction, existing studies have not yet defined a role for thermal flow detection.
To evaluate a revised test protocol using a micropumper designed to transiently enhance flow during thermal testing to determine whether thermal detection of flow is associated with progression to shunt revision surgery.
Eighty-two unique tests were performed in 71 shunts. The primary outcome, need for revision within 7 d of testing, was compared with results of micropumper-augmented thermal flow detection. Statistical analysis was based on blind interpretation of test results and raw temperature data recorded during testing.
The test was sensitive (73%) and specific (68%) in predicting need for revision, with 5.6-fold higher probability of revision when flow was not detected. Negative predictive value in our sample was 94.2%. The probability of not requiring revision increased with increasing total temperature drop. Analysis of various possible thresholds showed that the optimal temperature cutoff may be lower than suggested by the manufacturer (0.125°C vs 0.2°C).
This is the first study to report a strong association between thermal flow evaluation and a clinical impression that a shunt is not malfunctioning. The current recommended threshold may increase the false positive rate unnecessarily, and as clinicians gain experience with the method, they may find value in examining the temperature curves themselves. Multicenter studies are suggested to further define a role for this diagnostic test.
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Details
- Title
- Noninvasive Thermal Evaluation of Ventriculoperitoneal Shunt Patency and Cerebrospinal Fluid Flow Using a Flow Enhancing Device
- Creators
- Mustafa Q Hameed - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, MassachusettsDavid Zurakowski - Boston Children's HospitalMark R Proctor - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, MassachusettsScellig S D Stone - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, MassachusettsBenjamin C Warf - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, MassachusettsEdward R Smith - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, MassachusettsLiliana C Goumnerova - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, MassachusettsMarek Swoboda - Drexel UniversityTomer Anor - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, MassachusettsJoseph R Madsen - Department of Neurosurgery Boston Children's Hospital Harvard Medical School Boston, Massachusetts
- Publication Details
- Neurosurgery, v 85(2), pp 240-249
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000493103500086
- Scopus ID
- 2-s2.0-85066062556
- Other Identifier
- 991019168958904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery