Journal article
Noninvasive Ventilation in Newborns ≤ 1,500 g after Tracheal Extubation: Randomized Clinical Trial
American journal of perinatology, v 34(12), pp 1190-1198
Oct 2017
PMID: 28420011
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Objective
Our aim was to compare the success of extubation in neonates managed with nonsynchronized intermittent nasal positive-pressure ventilation (nsNIPPV) and two modes of nasal continuous positive airway pressure (NCPAP) after the first extubation.
Study Design
Randomized controlled clinical trial conducted in the neonatal intensive care unit (NICU) included infants with gestational age ≤ 34 weeks and birth weights (BW) 500 to 1,500 g with a diagnosis of respiratory distress syndrome (RDS), divided into three groups: ventilation with nsNIPPV, bubble-NCPAP, and ventilator-NCPAP. Extubation failure (EF) was defined as occurring within 48 hours after extubation.
Results
We included 101 newborns: nsNIPPV (
n
= 36); bubble-NCPAP (
n
= 32) ventilator-NCPAP (
n
= 33). Overall, the extubation success rate was 81.2%. There were no skin, gastric, or pulmonary complications related to noninvasive ventilation (NIV) (
p
= 1). There was no difference between the groups regarding the success/EF (
p
= 0.4). There was extubation success in 81 (81.2%) cases, and EF occurred in 20 (19.8%), associated with longer invasive mechanical ventilation time (
p
< 0.001) and development of bronchopulmonary dysplasia (
p
= 0.04).
Conclusion
In this trial, three modalities of NIV applied in the success/failure outcomes of extubation avoided reintubation in 80% of infants.
Metrics
Details
- Title
- Noninvasive Ventilation in Newborns ≤ 1,500 g after Tracheal Extubation: Randomized Clinical Trial
- Creators
- Simone Nascimento Santos Ribeiro - Rua Cardeal StepinacMaria Jussara Fernandes Fontes - Universidade Federal de Minas GeraisVineet Bhandari - St. Christopher's Hospital for ChildrenCamilla Borges Resende - Respiratory Care, Belo Horizonte, MG, BrazilCintia Johnston - Federal University of São Paulo
- Publication Details
- American journal of perinatology, v 34(12), pp 1190-1198
- Publisher
- Thieme Medical Publishers
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000411865900004
- Scopus ID
- 2-s2.0-85017642090
- Other Identifier
- 991019167416104721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics