Journal article
Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: pilot human study
Journal of Biomedical Optics, v 14(6), pp 064032-0640310
29 Dec 2009
PMID: 20059270
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A pilot human study is conducted to evaluate the potential of using diffuse photon density wave (DPDW) methodology at near-infrared (NIR) wavelengths
to monitor changes in tissue hemoglobin concentration in diabetic foot ulcers. Hemoglobin concentration is measured by DPDW in 12 human wounds for a period ranging from
. In all wounds that healed completely, gradual decreases in optical absorption coefficient, oxygenated hemoglobin concentration, and total hemoglobin concentration are observed between the first and last measurements. In nonhealing wounds, the rates of change of these properties are nearly zero or slightly positive, and a statistically significant difference
is observed in the rates of change between healing and nonhealing wounds. Differences in the variability of DPDW measurements over time are observed between healing and nonhealing wounds, and this variance may also be a useful indicator of nonhealing wounds. Our results demonstrate that DPDW methodology with a frequency domain NIR device can differentiate healing from nonhealing diabetic foot ulcers, and indicate that it may have clinical utility in the evaluation of wound healing potential.
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Details
- Title
- Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: pilot human study
- Creators
- Elisabeth S Papazoglou - Drexel UniversityMichael Neidrauer - Drexel UniversityLeonid Zubkov - Drexel UniversityMichael S Weingarten - Drexel UniversityKambiz Pourrezaei - Drexel University
- Publication Details
- Journal of Biomedical Optics, v 14(6), pp 064032-0640310
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000274267900039
- Scopus ID
- 2-s2.0-77950355595
- Other Identifier
- 991019168796004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Optics
- Radiology, Nuclear Medicine & Medical Imaging