Journal article
Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study
Journal of Biomedical Optics, v 11(6), pp 064021-0640213
22 Nov 2006
PMID: 17212544
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO2), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, StO2, and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO2, and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7±9.7)% in the first week and decreases (42.4±7.0)% in the second week. Averaged StO2 increases from (62.9±3.4)% baseline value to (70.4±3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7±7.0) [μM] to (73.3±8.3) [μM] at the end of the second week and to (63.0±8.1) [μM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.
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Details
- Title
- Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study
- Creators
- Ulas Sunar - University of PennsylvaniaHarry Quon - University of PennsylvaniaTurgut Durduran - University of PennsylvaniaJun Zhang - University of PennsylvaniaJuan Du - University of PennsylvaniaChao Zhou - University of PennsylvaniaGuoqiang Yu - University of PennsylvaniaRegine Choe - University of PennsylvaniaAlex Kilger - University of PennsylvaniaRobert Lustig - University of PennsylvaniaLaurie Loevner - University of PennsylvaniaShoko Nioka - University of PennsylvaniaBritton Chance - University of PennsylvaniaArjun G Yodh - University of Pennsylvania
- Publication Details
- Journal of Biomedical Optics, v 11(6), pp 064021-0640213
- Publisher
- Society of Photo-Optical Instrumentation Engineers (SPIE)
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000243968700024
- Scopus ID
- 2-s2.0-33847254824
- Other Identifier
- 991019356337104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Optics
- Radiology, Nuclear Medicine & Medical Imaging