Journal article
Noninvasive monitoring of brain edema after hypoxia in newborn piglets
Pediatric research, v 83(2), pp 484-490
01 Feb 2018
PMID: 29069074
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Development of cerebral edema after brain injury carries a high risk for brain damage and death. The present study tests the ability of a noninvasive cerebral edema monitoring system that uses near-infrared spectroscopy (NIRS) with water as the chromophore of interest to detect brain edema following hypoxia.
METHODS: Ventilated piglets were exposed to hypoxia for 1 h, and then returned to normal oxygen levels for 4 h. An NIRS sensor was placed on the animal's head at baseline, and changes in light attenuation were converted to changes in H2O. Cerebral water content and aquaporin-4 protein (AQP4) expression were measured.
RESULTS: The system detected changes in NIRS-derived water signal as early as 2 h after hypoxia, and provided fivefold signal amplification, representing a 10% increase in brain water content and a sixfold increase in AQP4, 4 h after hypoxia. Changes in water signal correlated well with changes in cerebral water content (R = 0.74) and AQP4 expression (R = 0.97) in the piglet brain.
CONCLUSION: The data show that NIRS can detect cerebral edema early in the injury process, thus providing an opportunity to initiate therapy at an earlier and more effective time-point after an insult than is available with current technology.
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Details
- Title
- Noninvasive monitoring of brain edema after hypoxia in newborn piglets
- Creators
- Shadi N. Malaeb - St. Christopher's Hospital for ChildrenMeltem Izzetoglu - Villanova UniversityJane McGowan - St. Christopher's Hospital for ChildrenMaria Delivoria-Papadopoulos - St. Christopher's Hospital for Children
- Publication Details
- Pediatric research, v 83(2), pp 484-490
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- 4100068711 / Pennsylvania Department of Health 282812-3850 / Coulter-Drexel Translational Research Partnership Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000428377500013
- Scopus ID
- 2-s2.0-85044349207
- Other Identifier
- 991019168607404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics