Journal article
Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature
Pediatric and developmental pathology, v 23(6), pp 448-452
01 Dec 2020
PMID: 32755442
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Carcinoma originating from the surface epithelium of the nasopharynx is classified by the World Health Organization (WHO) as nasopharyngeal carcinoma (NPC) and has 3 main types: keratinizing squamous cell carcinoma (WHO type 1) and nonkeratinizing carcinoma, differentiated (WHO type II), and undifferentiated (WHO type III). Nonkeratinizing NPC is strongly associated with prior Epstein-Barr virus (EBV) infection. These tumors may be divided into differentiated and undifferentiated carcinoma. Histologically, the tumor is characterized by syncytia of large malignant cells with vesicular nuclei, conspicuous nucleoli, and easily observed mitotic figures. We report a case of a 14-year-old boy diagnosed with EBV and human papillomavirus (HPV)-positive NPC (WHO type 3) with cytogenetics showing the presence of mosaic trisomy 2. This case report brings to light a rare cytogenetic aberration to our knowledge only reported once before in the literature in a xenograft model.
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Details
- Title
- Nonkeratinizing Nasopharyngeal Carcinoma, Undifferentiated Type With Trisomy 2: A Case Report and Short Review of Cytogenetic and Molecular Literature
- Creators
- Francesco Pontoriero - St. Christopher's Hospital for ChildrenAyaka M. Silverman - St. Christopher's Hospital for ChildrenJudy M. Pascasio - St. Christopher's Hospital for ChildrenRenu Bajaj - St. Christopher's Hospital for Children
- Publication Details
- Pediatric and developmental pathology, v 23(6), pp 448-452
- Publisher
- Sage
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000558283500001
- Scopus ID
- 2-s2.0-85089022018
- Other Identifier
- 991021838148704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pathology
- Pediatrics