Journal article
Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh
Environmental health perspectives, v 116(2), pp 190-195
01 Feb 2008
PMID: 18288317
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions.
OBJECTIVES: We examined the relationship of the serum level of Clara cell protein CC 16-a novel biomarker for respiratory illnesses-with well As, total urinary As, and urinary As methylation indices.
METHODS: We conducted a cross-sectional study in nonsmoking individuals (n = 241) selected from a large cohort with a wide range of As exposure (0.1-761 mu g/L) from drinking water in Bangladesh. Total urinary As, urinary As metabolites, and serum CC16 were measured in urine and serum samples collected at baseline of the parent cohort study.
RESULTS: We observed an inverse association between urinary As and serum CC 16 among persons with skin lesions (beta = -0. 13, p = 0.01). We also observed a positive association between secondary methylation index in urinary As and CC16 levels (beta = 0. 12,,P = 0.05) in the overall study population; the association was stronger among people without skin lesions (beta = 0. 18, p = 0.04), indicating that increased methylation capability may be protective against As-induced respiratory damage. In a subsample of study participants undergoing spirometric measures (n = 3 1), we observed inverse associations between urinary As and predictive FEV1 (forced expiratory volume measured in 1 sec) (r = -0.37; FEV1/forced vital capacity ratio and primary methylation index (r = -0.42, p = 0.01).
CONCLUSIONS: The findings suggest that serum CC 16 may be a useful biomarker of epithelial lung damage in individuals with arsenical skin lesions. Also, we observed the deleterious respiratory effects of As exposure at concentrations lower than reported in earlier studies.
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Details
- Title
- Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh
- Creators
- Faruque Parvez - Columbia UniversityYu Chen - New York UniversityPaul W. Brandt-Rauf - Columbia UniversityAlfred Bernard - UCLouvainXavier Dumont - UCLouvainVesna Slavkovich - Columbia UniversityMaria Argos - Columbia UniversityJeanine D'Armiento - Columbia UniversityRobert Foronjy - Columbia UniversityM. Rashidul Hasan - Chest InstituteH. E. M. Mahbubul Eunus - Columbia UniversityJoseph H. Graziano - Columbia UniversityHabibul Ahsan - University of Chicago
- Publication Details
- Environmental health perspectives, v 116(2), pp 190-195
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 6
- Grant note
- R01CA102484 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P30 ES009089; P42 ES 10349; P30 ES 09089; P30 ES000260; P42 ES010349; ES 000260 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P30ES009089 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01 CA 102484; CA 016087; R01 CA107431; R01 CA102484; P30 CA016087; R01 CA 107431 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000252831800029
- Scopus ID
- 2-s2.0-40549124316
- Other Identifier
- 991019323774404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology