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Nonpharmacological Response in Hospitalized Children With Conduct Disorder
Journal article   Open access

Nonpharmacological Response in Hospitalized Children With Conduct Disorder

RICHARD P. Malone, JAMES F. Luebbert, MARY ANNE Delaney, KRISTA A. Biesecker, BRIDGET L. Blaney, AMY B. Rowan and MAGDA Campbell
Journal of the American Academy of Child and Adolescent Psychiatry, v 36(2)
1997
DOI: https://doi.org/10.1097/00004583-199702000-00015
PMID: 9031577
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1097/00004583-199702000-00015View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open

Abstract

aggressive behavior child conduct disorder hospitalization pharmacological treatments placebo
There is a paucity of research regarding the effects of hospitalization and/or the response to placebo in children with conduct disorder who are hospitalized for chronic and severe aggression. However, many children with this problem are hospitalized and immediately begin pharmacotherapy. In this report, the effects of hospitalization and placebo administration were examined. Subjects were forty-four children (37 males, 7 females) with conduct disorder, aged 9.83 to 17.14 years, who were hospitalized for chronic and severe aggression. This was a 4-week double-blind and placebo-controlled study with a 2-week single-blind placebo lead-in period. During the 2-week placebo baseline period, aggression was measured on a 24-hour basis, using the Overt Aggression Scale. Only subjects meeting a specific aggression criterion were randomized to the treatment period of the trial. Of the 44 subjects enrolled, 23 (52.3%) met the aggression criteria for entering the treatment period (baseline nonresponders), while 21 (47.7%) did not (baseline responders). Thus, almost half of the subjects, while taking no active medication, benefited from the inpatient milieu/structure and/or placebo. This finding has important treatment and research implications. Medication to treat aggression should not be initiated immediately upon hospitalization because improvements associated with hospitalization may be attributed inaccurately to pharmacotherapy, resulting in unnecessarily medicating children. A placebo baseline period is essential to decrease the risk of a type II error in pharmacological research concerning aggression.

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37 citations in Web of Science
43 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Pediatrics
Psychiatry
Psychology, Developmental
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