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Nonpolarized signaling reveals two distinct modes of 3D cell migration
Journal article   Open access   Peer reviewed

Nonpolarized signaling reveals two distinct modes of 3D cell migration

Ryan J. Petrie, Nuria Gavara, Richard S. Chadwick and Kenneth M. Yamada
The Journal of cell biology, v 197(3), pp 439-455
30 Apr 2012
PMID: 22547408
url
https://rupress.org/jcb/article-pdf/197/3/439/1355673/jcb_201201124.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1083/jcb.201201124View
Published, Version of Record (VoR) Open

Abstract

Cell Biology Life Sciences & Biomedicine Science & Technology
We search in this paper for context-specific modes of three-dimensional (3D) cell migration using imaging for phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and active Rac1 and Cdc42 in primary fibroblasts migrating within different 3D environments. In 3D collagen, PIP3 and active Rac1 and Cdc42 were targeted to the leading edge, consistent with lamellipodia-based migration. In contrast, elongated cells migrating inside dermal explants and the cell-derived matrix (CDM) formed blunt, cylindrical protrusions, termed lobopodia, and Rac1, Cdc42, and PIP3 signaling was nonpolarized. Reducing RhoA, Rho-associated protein kinase (ROCK), or myosin II activity switched the cells to lamellipodia-based 3D migration. These modes of 3D migration were regulated by matrix physical properties. Specifically, experimentally modifying the elasticity of the CDM or collagen gels established that nonlinear elasticity supported lamellipodia-based migration, whereas linear elasticity switched cells to lobopodia-based migration. Thus, the relative polarization of intracellular signaling identifies two distinct modes of 3D cell migration governed intrinsically by RhoA, ROCK, and myosin II and extrinsically by the elastic behavior of the 3D extracellular matrix.

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Cell Biology
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