Journal article
Nonthermal plasma as part of a novel strategy for vaccination
Plasma processes and polymers, v 17(10, Special Issue: Advanced Applications of Plasmas in Life Sciences)
13 Jul 2020
PMID: 32837491
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vaccination has been one of the most effective health intervention mechanisms to reduce morbidity and mortality associated with infectious diseases. Vaccines stimulate the body's protective immune responses through controlled exposure to modified versions of pathogens that establish immunological memory. However, only a few diseases have effective vaccines. The biological effects of nonthermal plasma on cells suggest that plasma could play an important role in improving efficacy of existing vaccines and overcoming some of the limitations and challenges with current vaccination strategies. This review summarizes the opportunities for nonthermal plasma for immunization and therapeutic purposes.
Nonthermal plasma enhances innate and adaptive immune responses to infected cells. Nonthermal plasma induces oxidative stress in infected cells, increasing their immunogenicity and promoting recruitment of antigen presenting cells for phagocytic uptake. Antigen presenting cells then process pathogen antigens from the dead cell and migrate to the lymph nodes where they present the antigens to immune cells that mount an adaptive immune response and facilitate clearance of the infection.
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Details
- Title
- Nonthermal plasma as part of a novel strategy for vaccination
- Creators
- Hager Mohamed - Drexel UniversityRita A. Esposito - Drexel UniversityMichele A. Kutzler - Drexel UniversityBrian Wigdahl - Drexel UniversityFred C. Krebs - Drexel UniversityVandana Miller - Drexel University
- Publication Details
- Plasma processes and polymers, v 17(10, Special Issue: Advanced Applications of Plasmas in Life Sciences)
- Publisher
- John Wiley and Sons Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000578457300001
- Scopus ID
- 2-s2.0-85087785510
- Other Identifier
- 991019168817204721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Physics, Applied
- Physics, Condensed Matter
- Physics, Fluids & Plasmas
- Polymer Science