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Noradrenergic control of neurobehavior in human binge‐eating disorder and obesity ( NOBEAD ): A smartphone‐supported behavioral emotion regulation intervention study protocol integrating molecular brain imaging
Journal article   Open access   Peer reviewed

Noradrenergic control of neurobehavior in human binge‐eating disorder and obesity ( NOBEAD ): A smartphone‐supported behavioral emotion regulation intervention study protocol integrating molecular brain imaging

Swen Hesse, Michael Rullmann, Franziska Zientek, Danielle Schewe, Georg‐Alexander Becker, Marianne Patt, Philipp M. Meyer, Adrienne S. Juarascio, Guido K. W. Frank, Osama Sabri, …
The International journal of eating disorders
08 Nov 2023
DOI: https://doi.org/10.1002/eat.24080
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1002/eat.24080View
Published, Version of Record (VoR) Open

Abstract

Abstract Objective The neurobehavioral underpinnings of binge‐eating disorder (BED), co‐occurring with obesity (OB), are largely unknown. This research project conceptualizes BED as a disorder with dysfunctional emotion regulation (ER) linked with changes in central noradrenaline (NA) transmission and NA‐modulated neuronal networks. Methods We expect abnormalities in NA activity in both BED and OB, but most pronounced in BED. We expect these abnormalities to be modifiable through state‐of‐the‐art ER intervention, specifically in BED. To assess the role of NA transmission, we will quantify changes in NA transporter (NAT) availability using the highly NAT‐specific [ 11 C]methylreboxetin (MRB) and positron emission tomography‐magnetic resonance imaging (PET‐MRI) that allows measuring molecular and neuronal changes before and after an ER intervention. Individual 12‐session smartphone‐supported acceptance‐based behavioral therapy will be conducted to improve ER. Thirty individuals with OB and BED (OB + BED), 30 individuals with OB without BED (OB ‐ BED), and 20 individuals with normal weight will undergo assessments of NAT availability and neuronal network activity under rest and stimulated conditions, clinical interviews, self‐report questionnaires on eating behavior, ER, mental and physical health, and quality of life, and neuropsychological tests on executive function. Afterwards, in an experimental randomized‐controlled design, individuals with OB + BED and OB ‐ BED will be allocated to smartphone‐supported ER intervention versus a waitlist and re‐assessed after 10 weeks. Discussion By obtaining biological and behavioral markers, the proposed study will disentangle the involvement of NAT and the central NA system in the modulation of emotion‐supporting neuronal networks that influence eating behavior. Neurobehavioral mechanisms of change during an ER intervention will be determined. Trial Registration German Clinical Trials Register (DRKS): DRKS00029367. Public Significance This study investigates the central noradrenaline system by using hybrid brain imaging in conjunction with emotion regulation as a putative core biological mechanism in individuals with obesity with or without binge‐eating disorder that is targeted by emotion regulation intervention. The results will provide a molecular signature beyond functional imaging biomarkers as a predictive biomarker toward precision medicine for tailoring treatments for individuals with binge‐eating disorders and obesity.

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6 Record Views
4 citations in Web of Science
4 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#5 Gender Equality
#3 Good Health and Well-Being

InCites Highlights

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Nutrition & Dietetics
Psychiatry
Psychology
Psychology, Clinical
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