Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Noradrenergic modulation of wakefulness/arousal
Sleep medicine reviews, v 16(2), pp 187-197
Apr 2012
PMID: 22296742
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. State-dependent neuronal discharge activity of locus coeruleus noradrenergic neurons has long-suggested a role of this system in the induction of an alert waking state. Work over the past two decades provides unambiguous evidence that the locus coeruleus, and likely other noradrenergic nuclei, exert potent wake-promoting actions via an activation of noradrenergic β- and α1-receptors located within multiple subcortical structures, including the general regions of the medial septal area, the medial preoptic area and, most recently, the lateral hypothalamus. Conversely, global blockade of β- and α1-receptors or suppression of norepinephrine release results in profound sedation. The wake-promoting action of central noradrenergic neurotransmission has clinical implications for treatment of sleep/arousal disorders, such as insomnia and narcolepsy, and clinical conditions associated with excessive arousal, such as post-traumatic stress disorder.
Metrics
Details
- Title
- Noradrenergic modulation of wakefulness/arousal
- Creators
- Craig W. Berridge - University of Wisconsin–MadisonBrooke E. Schmeichel - University of Wisconsin–MadisonRodrigo A. España - Wake Forest University
- Publication Details
- Sleep medicine reviews, v 16(2), pp 187-197
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000301308200008
- Scopus ID
- 2-s2.0-84856802069
- Other Identifier
- 991019292137604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences