Journal article
Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex
Brain research, Vol.1641(Pt B), pp.217-233
15 Jun 2016
PMCID: PMC4879059
PMID: 26790349
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Among the neuromodulators that regulate prefrontal cortical circuit function, the catecholamine transmitters norepinephrine (NE) and dopamine (DA) stand out as powerful players in working memory and attention. Perturbation of either NE or DA signaling is implicated in the pathogenesis of several neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), post-traumatic stress disorder (PTSD), schizophrenia, and drug addiction. Although the precise mechanisms employed by NE and DA to cooperatively control prefrontal functions are not fully understood, emerging research indicates that both transmitters regulate electrical and biochemical aspects of neuronal function by modulating convergent ionic and synaptic signaling in the prefrontal cortex (PFC). This review summarizes previous studies that investigated the effects of both NE and DA on excitatory and inhibitory transmissions in the prefrontal cortical circuitry. Specifically, we focus on the functional interaction between NE and DA in prefrontal cortical local circuitry, synaptic integration, signaling pathways, and receptor properties. Although it is clear that both NE and DA innervate the PFC extensively and modulate synaptic function by activating distinctly different receptor subtypes and signaling pathways, it remains unclear how these two systems coordinate their actions to optimize PFC function for appropriate behavior. Throughout this review, we provide perspectives and highlight several critical topics for future studies. This article is part of a Special Issue entitled SI: Noradrenergic System.
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Details
- Title
- Norepinephrine versus dopamine and their interaction in modulating synaptic function in the prefrontal cortex
- Creators
- Bo Xing - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia PA 19129, United StatesYan-Chun Li - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia PA 19129, United StatesWen-Jun Gao - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia PA 19129, United States. Electronic address: wgao@drexelmed.edu
- Publication Details
- Brain research, Vol.1641(Pt B), pp.217-233
- Publisher
- Elsevier; Netherlands
- Grant note
- R03 MH101578 / NIMH NIH HHS R01 MH085666 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Identifiers
- 991014878281704721
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