Journal article
Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?
Translational vision science & technology, v 14(5), p13
01 May 2025
PMID: 40354067
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: Retinal nerve fiber layer thickness (RNFLT), a glaucoma biomarker, has a wide normative range affecting its sensitivity and specificity for abnormality detection. The interindividual RNFLT peak location variability contribution to this wide normative range has not been directly evaluated. The purpose of this study is to assess the effect of RNFLT peak normalization (PN) on normative variability. Methods: Circumpapillary RNFLT profiles at 1.7 mm radius from the optic nerve head (ONH) were re-sampled from optical coherence tomography (OCT) volumes (Cirrus HD-OCT, 200 x 200) obtained from one eye of 83 healthy individuals. Fovea-ONH axis (FOA) was calculated from corresponding scanning laser ophthalmoscope images. Supratemporal (ST) and infratemporal (IT) RNFLT peaks of each profile were aligned to respective average peak locations. Normative ranges were calculated by averaging individual profiles before and after PN (with and without FOA to horizontal image axis (HA) alignment). Results: RNFLT-PN resulted in an overall decrease in coefficient of variation (CoV) of the normative range by 4.2% (P = 0.02). CoV was reduced by more than 10% in clock-hours 10 (11.9%), 8 (10.6%), 6 (10.4%) after PN, and 7 (16.3%), 10 (11.4%), and 12 (10.4%) after PN with FOA-HA alignment. RNFLT-PN corrected for abnormality categorization because of peak misalignment in RNFLT profiles of healthy and glaucoma suspect subjects. Conclusions: RNFLT-PN reduces normative variability, especially in the ST and IT regions. Translational Relevance: RNFLT-PN reduces normative variability and improves sectoral abnormality categorization, potentially leading to better sensitivity and specificity of RNFLT measure in glaucoma detection.
Metrics
1 Record Views
Details
- Title
- Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?
- Creators
- Sowjanya Gowrisankaran - Oregon Health & Science UniversityAshkan Abbasi - Oregon Health & Science UniversityXubo Song - Oregon Health & Science UniversityJoel S. Schuman - Drexel UniversityGadi Wollstein - Wills Eye HospitalBhavna J. Antony - Federation UniversityHiroshi Ishikawa - Oregon Health & Science University
- Publication Details
- Translational vision science & technology, v 14(5), p13
- Publisher
- Assoc Research Vision Ophthalmology Inc
- Number of pages
- 12
- Grant note
- Malcolm M. Marquis, MD Endowed Fund for Innovation R01EY030929; R01EY013178; P30 EY010572 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Research to Prevent Blindness (New York, NY); Research to Prevent Blindness (RPB)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering and Science
- Web of Science ID
- WOS:001505231700019
- Scopus ID
- 2-s2.0-105005235993
- Other Identifier
- 991022197324204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology