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Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease
Journal article   Peer reviewed

Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease

Mehul H Nagarsheth, Alex Viehman, Sara M Lippa and Carol F Lippa
Journal of the neurological sciences, v 244(1-2), pp 111-116
15 May 2006
DOI: https://doi.org/10.1016/j.jns.2006.01.007
PMID: 16473372
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Dementia - metabolism Dementia - pathology Dementia - physiopathology Female Hippocampus - metabolism Hippocampus - pathology Humans Immunohistochemistry Male Middle Aged Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Neurons - metabolism Neurons - pathology Pick Disease of the Brain - metabolism Pick Disease of the Brain - pathology Predictive Value of Tests Receptor, Notch1 - metabolism tau Proteins - metabolism Up-Regulation - physiology
Notch-1 is a protein that influences cell fate decisions, with its expression occurring primarily during embryogenesis and development. However, Notch-1 is also expressed in the adult brain, in regions with high synaptic plasticity, particularly the hippocampus. Its role in adults is unknown; however, it may impact neurite outgrowth or cell differentiation in adult brain regions undergoing neurogenesis. Notch-1 is increased in Alzheimer's disease (AD); however, its expression in other CNS degenerative diseases has not been described. To begin to define the range of degenerative disorders where Notch-1 expression is altered, we examined Notch-1 immunoreactivity in a variety of neurodegenerative diseases to determine whether its increase is selective for AD. We examined sections of hippocampus from 13 AD, 13 classical Pick's disease (PiD; with Pick bodies), 4 dementia lacking distinctive histopathology (DLDH) and 8 control brains, emphasizing hippocampal (dentate gyrus) pathology. We determined that Notch-1 immunoexpression is increased in AD and PiD relative to control cases. DLDH cases were not significantly different than control cases with respect to Notch-1 expression. Given the increase in Notch-1 immunoexpression in AD and PiD, two diseases where abnormal tau aggregates are present, and the lack of Notch-1 immunoexpression in DLDH (where tau aggregates are absent), we cannot rule out the possibility that tau aggregates are associated with Notch-1 expression in neurodegenerative diseases.

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Web of Science research areas
Clinical Neurology
Neurosciences
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