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Journal article
Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington’s disease
Frontiers in behavioral neuroscience, v 17
07 Jun 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Glutamate excitotoxicity is causal in striatal neurodegeneration underlying motor dysfunction and cognitive deficits in Huntington’s disease (HD). Excitatory amino acid transporter 2 (EAAT2), the predominant glutamate transporter accounting for > 90% of glutamate transport, plays a key role in preventing excitotoxity by clearing excess glutamate from the intrasynaptic cleft. Accordingly, EAAT2 has emerged as a promising therapeutic target for prevention of neuronal excitotoxicity underlying HD and other neurodegenerative diseases.
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Details
- Title
- Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington’s disease
- Creators
- Akanksha Bhatnagar - Drexel UniversityVisha Parmar - Drexel UniversityNicholas Barbieri - Drexel UniversityFrank Bearoff - Drexel UniversityFelice Elefant - Drexel UniversitySandhya Kortagere - Drexel University
- Publication Details
- Frontiers in behavioral neuroscience, v 17
- Publisher
- Frontiers Research Foundation
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Biology
- Web of Science ID
- WOS:001010142600001
- Scopus ID
- 2-s2.0-85162998186
- Other Identifier
- 991020594314704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences