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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Novel HIV-1 therapeutics through targeting altered host cell pathways
Expert opinion on biological therapy, v 9(11), pp 1369-1382
01 Nov 2009
PMID: 19732026
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The emergence of drug-resistant HIV-1 strains presents a challenge for the design of new drugs. Anti-HIV compounds currently in use are the subject of advanced clinical trials using either HIV-1 reverse transcriptase, viral protease or integrase inhibitors. Recent studies show an increase in the number of HIV-1 variants resistant to anti-retroviral agents in newly infected individuals. Targeting host cell factors involved in the regulation of HIV-1 replication might be one way to combat HIV-1 resistance to the currently available antiviral agents. A specific inhibition of HIV-1 gene expression could be expected from the development of compounds targeting host cell factors that participate in the activation of the HIV-1 LTR promoter. Here we discuss how targeting the host can be accomplished either by using small molecules to alter the function of the host's proteins such as p53 or cdk9, or by utilizing new advances in siRNA therapies to knock down essential host factors such as CCR5 and CXCR4. Finally, we will discuss how the viral protein interactomes should be used to better design therapeutics against HIV-1.
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Details
- Title
- Novel HIV-1 therapeutics through targeting altered host cell pathways
- Creators
- William Coley - George Washington UniversityKylene Kehn-Hall - George Washington UniversityRachel Van Duyne - George Washington UniversityFatah Kashanchi - George Washington University
- Publication Details
- Expert opinion on biological therapy, v 9(11), pp 1369-1382
- Publisher
- Taylor & Francis
- Number of pages
- 14
- Grant note
- R21 AI071903; R21 AI071903-02; R01 AI043894 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01AI043894 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000271454300003
- Scopus ID
- 2-s2.0-70350635526
- Other Identifier
- 991021902521604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Medicine, Research & Experimental