Journal article
Novel Object Recognition in the Rat: A Facile Assay for Cognitive Function
Current Protocols in Pharmacology, v 49(1), pp 5.59.1-5.59.15
Jun 2010
PMID: 22294372
Abstract
The rat novel object recognition (NOR) assay is a relatively high‐throughput, robust, and sensitive procedure for evaluating compounds for cognition‐enhancing activity. For the test, rats are given the opportunity to explore two identical objects for a predetermined period of time. After a delay, the animals are then presented with two objects to explore, one of which is the same as in the first exploration trial, the other a new object. Depending on the length of the delay between the two trials, the rats will either explore the novel object for a greater time period, indicating memory for the familiar object, or will explore the novel and familiar objects for the same amount of time, indicating a lack of recall or loss of memory for the familiar object presented during the initial trial. The protocol described in this unit can be used to evaluate the effects of a compound on the short‐term/working memory of adult male rats following a 24‐hr inter‐trial interval. Curr. Protoc. Pharmacol. 49:5.59.1‐5.59.15. © 2010 by John Wiley & Sons, Inc.
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100 citations in Scopus
Details
- Title
- Novel Object Recognition in the Rat: A Facile Assay for Cognitive Function
- Creators
- Joanne R. Mathiasen - Discovery Research, CephalonAmy DiCamillo - Discovery Research, Cephalon
- Publication Details
- Current Protocols in Pharmacology, v 49(1), pp 5.59.1-5.59.15
- Publisher
- Wiley
- Number of pages
- 15
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Scopus ID
- 2-s2.0-77953841496
- Other Identifier
- 991021900018204721