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Journal article
Novel Oncogene Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression Signatures
Cancer research (Chicago, Ill.), v 73(2), pp 978-989
30 Nov 2012
PMCID: PMC3561759
PMID: 23204233
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Herein, murine prostate cancer cell lines, generated via selective transduction with a single oncogene (c-Myc, Ha-Ras, and v-Src), demonstrated oncogene-specific prostate cancer molecular signatures that were recapitulated in human prostate cancer, and developed lung metastasis in immune competent mice. Interrogation of two independent retrospective cohorts of patient samples using the oncogene signature demonstrated an ability to distinguish tumor from normal prostate with a predictive value for prostate cancer of 98 – 99%. In a blinded study, the signature algorithm demonstrated independent substratification of reduced recurrence free survival by Kaplan-Meier analysis. The generation of new oncogene-specific prostate cancer cell lines that recapitulate human prostate cancer gene expression, that metastasize in immune-competent mice, are a valuable new resource for testing targeted therapy while the molecular signatures identified herein provides further value over current gene signature markers of prediction and outcome.
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Details
- Title
- Novel Oncogene Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression Signatures
- Creators
- Xiaoming Ju - Thomas Jefferson UniversityAdam Ertel - Thomas Jefferson UniversityMathew Casimiro - Kimmel Cancer CenterZuoren Yu - Kimmel Cancer CenterHui Meng - Kimmel Cancer CenterPeter A. McCue - Thomas Jefferson UniversityRhonda Walters - Thomas Jefferson UniversityPaolo Fortina - Thomas Jefferson UniversityMichael P. Lisanti - Thomas Jefferson UniversityRichard G. Pestell - Thomas Jefferson University
- Publication Details
- Cancer research (Chicago, Ill.), v 73(2), pp 978-989
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- R01 CA086072 || CA / National Cancer Institute : NCI P30 CA056036 || CA / National Cancer Institute : NCI R01 CA070896 || CA / National Cancer Institute : NCI R01 CA075503 || CA / National Cancer Institute : NCI R01 CA107382 || CA / National Cancer Institute : NCI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000313739500055
- Scopus ID
- 2-s2.0-84872563780
- Other Identifier
- 991019176803604721
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- Web of Science research areas
- Oncology