Journal article
Novel Polysulfated Galactose-Derivatized Dendrimers as Binding Antagonists of Human Immunodeficiency Virus Type 1 Infection
Antimicrobial agents and chemotherapy, v 48(5), pp 1614-1623
May 2004
PMID: 15105112
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidence indicates that galactosyl ceramide (GalCer) and its 3′-sulfated derivative, sulfatide (SGalCer), may act as alternate coreceptors for human immunodeficiency virus type 1 (HIV-1) in CD4
−
cells. Glycosphingolipids (GSLs) may also be necessary for fusion of HIV-1 and host cell membranes. Using an enzyme-linked immunosorbent assay to determine which GSL was the best ligand for both recombinant and virus-associated gp120, we found that SGalCer was the best ligand for each rgp120 and HIV-1 isolate tested. Therefore, novel multivalent glycodendrimers, which mimic the carbohydrate clustering reportedly found in lipid rafts, were synthesized based on the carbohydrate moiety of SGalCer. Here we describe the synthesis of a polysulfated galactose functionalized, fifth generation DAB dendrimer (PS Gal 64mer), containing on average two sulfate groups per galactose residue. Its ability to inhibit HIV-1 infection of cultured indicator cells was compared to that of dextran sulfate (DxS), a known, potent, binding inhibitor of HIV-1. The results indicate that the PS Gal 64mer inhibited infection by the HIV-1 isolates tested as well as DxS.
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Details
- Title
- Novel Polysulfated Galactose-Derivatized Dendrimers as Binding Antagonists of Human Immunodeficiency Virus Type 1 Infection
- Creators
- Richard D Kensinger - Department of Biochemistry and Molecular BiologyBradley J Catalone - Department of Biochemistry and Molecular BiologyFred C Krebs - Department of Biochemistry and Molecular BiologyBrian Wigdahl - Department of Biochemistry and Molecular BiologyCara-Lynne Schengrund - Department of Biochemistry and Molecular Biology
- Publication Details
- Antimicrobial agents and chemotherapy, v 48(5), pp 1614-1623
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000221227900022
- Scopus ID
- 2-s2.0-2142770270
- Other Identifier
- 991014878430904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Pharmacology & Pharmacy