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Published, Version of Record (VoR)CC BY-NC V4.0, Open
Journal article
Novel Therapeutics: Can Hydrogels Work to Treat Kidney Disease?
Nephron (2015), pp 1-1
25 Jul 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUNDHydrogels are water-swollen networks that can be made from a variety of natural and synthetic polymers. Numerous chemistries can be utilized to formulate hydrogels that are injectable, enabling facile in situ delivery of therapeutics such as cytokines or cells. SUMMARYCells delivered via injectable hydrogels survive injection better than cells injected in saline or media suspension. Several materials have been used to investigate the use of injectable hydrogels to treat animal models of kidney disease. Species studied to date include mice and rats. This review summarizes the various materials, encapsulated therapeutic payloads and preclinical models of kidney disease employed to investigate hydrogel injection. Transcutaneous measurements of glomerular filtration rate have demonstrated that delivery of hydrogels under the kidney capsule does not impair kidney function. KEY MESSAGESStudies to date have shown the safety and efficacy of hydrogel therapies to treat kidney disease, and numerous studies have demonstrated that hydrogel therapy alone reduces inflammation and fibrosis.
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Details
- Title
- Novel Therapeutics: Can Hydrogels Work to Treat Kidney Disease?
- Creators
- Danielle E SorannoChristopher B Rodell
- Publication Details
- Nephron (2015), pp 1-1
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001036980200001
- Scopus ID
- 2-s2.0-85179844138
- Other Identifier
- 991020840015704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Urology & Nephrology