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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension
Journal of perinatology, v 40(11), pp 1634-1643
01 Nov 2020
PMID: 32811975
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To quantify and compare levels of potential biomarkers in neonates with (i) Bronchopulmonary dysplasia (BPD); (ii) BPD-associated pulmonary hypertension (BPD-PH); (iii) PH without BPD; and (iv) neonates without lung disease at similar to 36 weeks postmenstrual age.
Study design Multiple potential biomarkers were measured in plasma samples of 90 patients using a multi-spot enzyme-linked immunosorbent assay. Statistical tests done included one-way ANOVA to compare levels of biomarkers between different groups.
Results Higher levels of ICAM-1 were present in infants with BPD and correlated with its severity. Infants with BPD have significantly higher levels of ANG-2 and lower levels of ANG-1. Infants with PH have higher levels of: IL-6, IL-8, IL-10, and TNF-alpha. Infants with BPD-PH have significantly lower levels of MCP-1 and higher levels of IL-1 beta than infants with PH without BPD.
Conclusion ICAM-1 may be used as a specific biomarker for diagnosis of BPD and its severity.
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Details
- Title
- Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension
- Creators
- Mitali Sahni - Sunrise MedicalBettie Yeboah - St. Christopher's Hospital for ChildrenPragnya Das - Cooper University HospitalDilip Shah - Cooper University HospitalDevasena Ponnalagu - The Ohio State UniversityHarpreet Singh - The Ohio State UniversityLeif D. Nelin - Nationwide Children's HospitalVineet Bhandari - Cooper University Hospital
- Publication Details
- Journal of perinatology, v 40(11), pp 1634-1643
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- R01-HL133050 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 16GRNT29430000 / American Heart Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000561267400001
- Scopus ID
- 2-s2.0-85089526842
- Other Identifier
- 991019167537204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics