Journal article
Novel polyphosphazene/poly(lactide- co-glycolide) blends: miscibility and degradation studies
Biomaterials, v 18(23), pp 1565-1569
1997
PMID: 9430340
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A novel biodegradable polymer blend was developed for potential biomedical applications. A 50:50 poly(lactide-co-glycolide) (PLAGA) was blended in a 50:50 ratio with the followiing polyphosphazenes (PPHOS): poly[(25% ethyl glycinato)(75%
p-methylphenoxy)phosphazene[, poly[(50% ethyl glycinato)(50%
p-methylphenoxy)phosphazene], and poly[(75% ethyl glycinato)(25%
p-methylphenoxy)phosphazene] to obtain Blends A, B, and C, respectively, using a mutual solvent technique. The miscibility of these blends was determined by measuring their glass transition temperature (
T
g) using differential scanning calorimetry. After fabrication using a casting technique, the degradation of the matrices was examined. Differential scanning calorimetry showed one glass transition temperature for each blend which was between the
T
g's of their respective parent polymers indicating miscibility of the blends. Surface analysis by scanning electron microscopy showed the matrices to have smooth uniform surfaces. Degradation studies showed near-zero order degradation kinetics for the blends with Blends A and B losing 10% of their mass after two weeks and Blend C degrading more rapidly (30% mass loss during the same period). These findings suggest that these novel biodegradable PLAGA/PPHOS blends may be useful for biomedical purposes.
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Details
- Title
- Novel polyphosphazene/poly(lactide- co-glycolide) blends: miscibility and degradation studies
- Creators
- Sobrasua E.M. Ibim - Department of Biology, Morris Brown College, Atlanta, GA, USAArchel M.A. Ambrosio - Allegheny University of the Health SciencesMichael S. Kwon - Allegheny University of the Health SciencesSaadiq F. El-Amin - Allegheny University of the Health SciencesHarry R. Allcock - Pennsylvania State UniversityCato T. Laurencin - Drexel University
- Publication Details
- Biomaterials, v 18(23), pp 1565-1569
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000070970100008
- Scopus ID
- 2-s2.0-0030667775
- Other Identifier
- 991019168891004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials