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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Novel whole blood transcriptome signatures of changes in maximal aerobic capacity in response to endurance exercise training in healthy women
Physiological genomics, v 55(8), pp 338-344
01 Aug 2023
PMID: 37335021
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Maximal aerobic exercise capacity [maximal oxygen consumption (V̇o
)] is one of the strongest predictors of morbidity and mortality. Aerobic exercise training can increase V̇o
, but inter-individual variability is marked and unexplained physiologically. The mechanisms underlying this variability have major clinical implications for extending human healthspan. Here, we report a novel transcriptome signature related to ΔV̇o
with exercise training detected in whole blood RNA. We used RNA-Seq to characterize transcriptomic signatures of ΔV̇o
in healthy women who completed a 16-wk randomized controlled trial comparing supervised, higher versus lower aerobic exercise training volume and intensity (4 training groups, fully crossed). We found significant baseline gene expression differences in subjects who responded to aerobic exercise training with robust versus little/no ΔV̇o
, and differentially expressed genes/transcripts were mostly related to inflammatory signaling and mitochondrial function/protein translation. Baseline gene expression signatures associated with robust versus little/no ΔV̇o
were also modulated by exercise training in a dose-dependent manner, and they predicted ΔV̇o
in this and a separate dataset. Collectively, our data demonstrate the potential utility of using whole blood transcriptomics to study the biology of inter-individual variability in responsiveness to the same exercise training stimulus.
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Details
- Title
- Novel whole blood transcriptome signatures of changes in maximal aerobic capacity in response to endurance exercise training in healthy women
- Creators
- Thomas J LaRocca - Colorado State UniversityMeghan E Smith - Colorado State UniversityKaitlin A Freeberg - University of Colorado BoulderDaniel H Craighead - University of Colorado BoulderTimothy Helmuth - University of Colorado BoulderMatthew M Robinson - Oregon State UniversityK Sreekumaran Nair - Mayo ClinicAngela D Bryan - University of Colorado BoulderDouglas R Seals - University of Colorado Boulder
- Publication Details
- Physiological genomics, v 55(8), pp 338-344
- Publisher
- American Physiological Society (APS)
- Grant note
- F31HL154782 / NHLBI NIH HHS 1R01CA179963-01 / NCI NIH HHS R21AG06302 / NIA NIH HHS K01HL153326 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Web of Science ID
- WOS:001037208600002
- Scopus ID
- 2-s2.0-85165793539
- Other Identifier
- 991021894712704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Genetics & Heredity
- Physiology