Journal article
Now on display: a gallery of group II intron structures at different stages of catalysis
Mobile DNA, v 4(1), pp 14-14
01 May 2013
PMID: 23634971
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been characterized first genetically, then biochemically, and finally by means of X-ray crystallography. To date, 17 crystal structures of a group II intron are available, representing five different stages of the splicing cycle. This review provides a framework for classifying and understanding these new structures in the context of the splicing cycle. Structural and functional implications for the spliceosome are also discussed.
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Details
- Title
- Now on display: a gallery of group II intron structures at different stages of catalysis
- Creators
- Marco Marcia - Yale UniversitySrinivas Somarowthu - Yale UniversityAnna Marie Pyle - Yale UniversityArgonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
- Publication Details
- Mobile DNA, v 4(1), pp 14-14
- Publisher
- BioMed Central
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000319898800001
- Scopus ID
- 2-s2.0-84878580948
- Other Identifier
- 991020837746304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity