Journal article
Nuak kinase signaling in development and disease of the central nervous system
Cellular signalling, v 100, 110472
Dec 2022
PMID: 36122883
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Protein kinases represent important signaling hubs for a variety of biological functions. Many kinases are traditionally studied for their roles in cancer cell biology, but recent advances in neuroscience research show repurposed kinase function to be important for nervous system development and function. Two members of the AMP-activated protein kinase (AMPK) related family, NUAK1 and NUAK2, have drawn attention in neuroscience due to their mutations in autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia, and intellectual disability (ID). Furthermore, Nuak kinases have also been implicated in tauopathy and other disorders of aging. This review highlights what is known about the Nuak kinases in nervous system development and disease and explores the possibility of Nuak kinases as targets for therapeutic innovation.
•A Nuak kinase family is implicated in neurodevelopment.•A Nuak kinase abnormality can lead to neurodevelopmental disorders.•Nuak kinases play an important role in aging and cancer development.•A number of types of cancer may be treatable by Nuak kinase inhibitors.
Metrics
Details
- Title
- Nuak kinase signaling in development and disease of the central nervous system
- Creators
- Sarah A. Bennison - Drexel UniversityXiaonan Liu - Drexel UniversityKazuhito Toyo-oka - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
- Publication Details
- Cellular signalling, v 100, 110472
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; Pharmacology and Physiology
- Web of Science ID
- WOS:000866559200001
- Scopus ID
- 2-s2.0-85139073222
- Other Identifier
- 991020100069104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology