Journal article
Nuclear Factor Kappa B Signaling Initiates Early Differentiation of Neural Stem Cells
Stem cells (Dayton, Ohio), v 30(3), pp 510-524
01 Mar 2012
PMID: 22134901
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inflammatory mediators, many of which activate the signaling of nuclear factor kappa B (NFκB), have received increasing attention in the field of neurogenesis. NFκB signaling regulates neurite outgrowth and neural plasticity as well as the proliferation/apoptosis and terminal differentiation of neural stem cells (NSCs). Early neurogenesis from NSCs produces identical progeny through symmetric division and committed daughter cells through asymmetric division. Here, we show that NFκB signaling is required for NSC initial differentiation. The canonical IKKβ/IκBα/ p65 pathway is activated during the initial stages of neural differentiation induced by treatment with TNFα or with- drawal of epidermal growth factor/basic fibroblast growth factor. NSC-specific inhibition of NFκB in transgenic mice causes an accumulation of Nestin
+
/Sox2
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/glial fibrillary acidic protein
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NSCs. Inhibition of NFκB signaling in vitro blocks differentiation and asymmetric division and maintains NSCs in an undifferentiated state. The induction of initial differentiation and asymmetry by NFκB signaling occurs through the inhibition of C/EBPβ expression. Our data reveal a novel function of NFκB signaling in early neurogenesis and provide insight into the molecular mechanisms underlying neurodevelopmental disorders and neurodegenerative diseases.
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Details
- Title
- Nuclear Factor Kappa B Signaling Initiates Early Differentiation of Neural Stem Cells
- Creators
- Yonggang Zhang - Temple UniversityJianjun Liu - Temple UniversityShaohua Yao - Sichuan UniversityFang Li - Temple UniversityLin Xin - Sichuan UniversityMowen Lai - Sichuan UniversityValerie Bracchi-Ricard - Emory UniversityHong Xu - Sichuan UniversityWilliam Yen - Temple UniversityWentong Meng - Sichuan UniversityShu Liu - Temple UniversityLeiting Yang - Emory UniversityShaffiat Karmally - Emory UniversityJin Liu - Sichuan UniversityHongyan Zhu - Sichuan UniversityJennifer Gordon - Temple UniversityKamel Khalili - Temple UniversityShanthi Srinivasan - Veterans Health AdministrationJohn R. Bethea - Emory UniversityXianming Mo - Sichuan UniversityWenhui Hu - Temple University
- Publication Details
- Stem cells (Dayton, Ohio), v 30(3), pp 510-524
- Publisher
- Wiley
- Grant note
- R21 OD011155 || OD / Office of the Director : NIH R01 DK075964 || DK / National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK R21 RR032123 || RR / National Center for Research Resources : NCRR
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000300611400019
- Scopus ID
- 2-s2.0-84863165023
- Other Identifier
- 991020100197504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Cell & Tissue Engineering
- Cell Biology
- Hematology
- Oncology