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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Nuclear factor-?B activation in schwann cells regulates regeneration and remyelination
Glia, v 60(4), pp 639-650
01 Apr 2012
PMID: 22275133
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Schwann cells (SCs) are crucial for peripheral nerve development and regeneration; however, the intrinsic regulatory mechanisms governing postinjury responses are poorly understood. Activation and deacetylation of nuclear factor-?B (NF- ?B) in SCs have been implicated as prerequisites for peripheral nerve myelination. Using GFAP-I?Ba-dn mice in which NF- ?B transcriptional activation is inhibited in SCs, we found no discernable differences in the quantity or structure of myelinated axons in adult facial nerves. Following crush injury, axonal regeneration was impaired at 31 days and significantly enhanced at 65 days in transgenic animals. Compact remyelination and Remak bundle organization were significantly compromised at 31 days and restored by 65 days post injury. Together, these data indicate that inhibition of NF-?B activation in SCs transiently delays axonal regeneration and compact remyelination. Manipulating the temporal activation of nuclear factor-?B in Schwann cells may offer new therapeutic avenues for PNS and CNS regeneration. (c) 2012 Wiley Periodicals, Inc.
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Details
- Title
- Nuclear factor-?B activation in schwann cells regulates regeneration and remyelination
- Creators
- Paul D. Morton - University of MiamiJoshua T. Johnstone - University of MiamiAngel Y. RamosDaniel J. Liebl - University of MiamiMary Bartlett Bunge - University of MiamiJohn R. Bethea - University of Miami
- Publication Details
- Glia, v 60(4), pp 639-650
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- T32 NS007459; NS51709 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32NS007459 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000300006700011
- Scopus ID
- 2-s2.0-84856749288
- Other Identifier
- 991020100112304721
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- Web of Science research areas
- Neurosciences