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Nucleation: the connections between equilibrium and kinetic behavior
Journal article   Peer reviewed

Nucleation: the connections between equilibrium and kinetic behavior

Frank A Ferrone
Methods in enzymology, v 412, pp 285-299
2006
PMID: 17046664

Abstract

Thermodynamics Hemoglobin, Sickle - chemistry Models, Biological Anemia, Sickle Cell - metabolism Humans Kinetics Hemoglobin, Sickle - metabolism Solutions - chemistry
This chapter describes the thermodynamics that govern the formation of nuclei, the least stable species in the reaction path of large, linear aggregates. In the approach described here, parameters are used that have direct molecular interpretations, such as contact energies of the molecular species. The extensive work on sickle hemoglobin is used as a model. An important result is that the nucleus size is expected to vary with initial conditions, such as the initial monomer concentration. Another unexpected result of some generality is that motion of the molecules within the nucleus recovers significant amounts of entropy that would be lost on complete immobilization.

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Web of Science research areas
Biochemical Research Methods
Biochemistry & Molecular Biology
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