Journal article
Nucleation: the connections between equilibrium and kinetic behavior
Methods in enzymology, v 412, pp 285-299
2006
PMID: 17046664
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Abstract
This chapter describes the thermodynamics that govern the formation of nuclei, the least stable species in the reaction path of large, linear aggregates. In the approach described here, parameters are used that have direct molecular interpretations, such as contact energies of the molecular species. The extensive work on sickle hemoglobin is used as a model. An important result is that the nucleus size is expected to vary with initial conditions, such as the initial monomer concentration. Another unexpected result of some generality is that motion of the molecules within the nucleus recovers significant amounts of entropy that would be lost on complete immobilization.
Metrics
Details
- Title
- Nucleation: the connections between equilibrium and kinetic behavior
- Creators
- Frank A Ferrone - Department of Physics, Drexel University, Philadelphia, Pennsylvania 19104, USA
- Publication Details
- Methods in enzymology, v 412, pp 285-299
- Publisher
- Elsevier; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000241828800017
- Scopus ID
- 2-s2.0-33749597429
- Other Identifier
- 991014877764204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology