Journal article
Nucleic acid electrochemical and electromechanical biosensors: a review of techniques and developments
Reviews in analytical chemistry, v 33(4), pp 213-230
01 Dec 2014
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This review comprises the last decade's development on experimental techniques for electrochemical and electromechanical sensing of nucleic acids, which originate from pathogenic bacteria, parasites, and viruses commonly found in food, water, and medical context. The electrochemical devices that are of primary interest are those that use voltammetry for detecting DNA and RNA-associated electrochemically active molecules at the working electrode. Attograms of nucleic acids have been reported to be detectable with electrochemical sensors in a batch-mode measurement arrangement. The mass-sensing electromechanical devices sense nucleic acids at the femtogram levels in a flow format without a molecular technique for amplifying target strand using polymerase chain reaction. Both underlying physics and methods of various studies are summarized, with discussion on limitations and potentials. We call attention to the need for sensors that not only detect but also confirm detection, as false negatives are not acceptable when one measures pathogenic species.
Metrics
Details
- Title
- Nucleic acid electrochemical and electromechanical biosensors: a review of techniques and developments
- Creators
- Ruben Rosario - Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USARaj Mutharasan - Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA
- Publication Details
- Reviews in analytical chemistry, v 33(4), pp 213-230
- Publisher
- Walter De Gruyter
- Number of pages
- 18
- Grant note
- CBET- 1159841 / NSF; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000345510600001
- Scopus ID
- 2-s2.0-84913537511
- Other Identifier
- 991019170853304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Analytical