Journal article
Numerical Investigation Into Bone Remodeling Around Different Co-Polymeric Swelling Bone Anchors
International journal for numerical methods in biomedical engineering, v 41(6), e70054
Jun 2025
PMID: 40548905
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study, a hygro-elastic finite element framework, along with a strain-energy-density based bone remodeling framework, was developed and used to simulate the swelling of co-polymeric bone anchors to investigate their hygro-mechanical response. To validate the numerical results, free swelling and in vivo experiments were conducted as well. The free swelling experiments were conducted on co-polymeric porous bone anchors (composed of cross-linked poly [methyl methacrylate-co-acrylic acid]) with two ratios of 80/20 and 90/10 to investigate their swelling characteristics in bovine serum, mimicking in vivo conditions. Subsequently, the swelling of bone anchors was simulated embedded in bone regions with different densities. The radial stresses induced in the interface were extracted to examine the mechanical response of the surrounding bone. According to Wolff's law, such mechanical loads can be regarded by bone mechanotransducers as stimuli for remodeling. The bone remodeling framework evaluated the impact of the radial force induced by the swelling of the bone anchor on the surrounding bone. The radial stress induced by the controlled swelling ratio of 90/10 composition resulted in favorable bone densification in the region of interest (approximately between 17.5% and 54% depending on the density of the region). However, the excessive swelling of 80/20 composition caused radial stresses to go beyond the threshold of 31 MPa, causing overload resorption in the interface (especially in high-density regions, where there was total resorption in the interface) and jeopardizing the success of the bone anchor and osteointegration. It was discovered that the swelling ratio plays an important role in bone remodeling, and that it must be controlled within a certain threshold to ensure bone densification and prevent overload resorption. The results of the in vivo sheep study also confirmed these findings.
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Details
- Title
- Numerical Investigation Into Bone Remodeling Around Different Co-Polymeric Swelling Bone Anchors
- Creators
- Amirreza Sadighi - Drexel UniversityMehrangiz Taheri - Drexel UniversityNolan Black - Drexel UniversityMoein Taghvaei - Drexel UniversityMadeline Boyes - University of PennsylvaniaDelaney Oeth - University of PennsylvaniaSorin Siegler - Drexel UniversityThomas P Schaer - University of PennsylvaniaAhmad R Najafi (Corresponding Author) - Drexel University
- Publication Details
- International journal for numerical methods in biomedical engineering, v 41(6), e70054
- Publisher
- Wiley
- Number of pages
- 24
- Grant note
- 4000027724 / The Commonwealth of Pennsylvania, Department of Community and Economic Development provided by the Manufacturing Pennsylvania Innovation Program to Carnegie Mellon and subcontracted to Drexel University (Subcontract No. 1060181-483741). A. R. Najafi's faculty start-up funding from the Department of Mechanical Engineering and Mechanics at Drexel University Coulter-Drexel Translational Research Partnership Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics; College of Engineering
- Web of Science ID
- WOS:001514093600006
- Scopus ID
- 2-s2.0-105008866621
- Other Identifier
- 991022060031504721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Mathematical & Computational Biology
- Mathematics, Interdisciplinary Applications