Journal article
Nutrient restriction and radiation therapy for cancer treatment: when less is more
The oncologist (Dayton, Ohio), v 18(1), pp 97-103
Jan 2013
PMID: 23299773
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer. Therefore, manipulation of these pathways using CR can render cancer cells, and most notably breast cancer cells, more susceptible to standard cytotoxic treatment with radiation and chemotherapy. In this review article we demonstrate the laboratory and clinical evidence that exists for CR and show compelling evidence through the molecular pathways CR induces about how it may be used as a treatment in tandem with radiation therapy to improve our rates of disease control.
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Details
- Title
- Nutrient restriction and radiation therapy for cancer treatment: when less is more
- Creators
- Colin E Champ - Thomas Jefferson UniversityRenato Baserga - Thomas Jefferson UniversityMark V Mishra - Thomas Jefferson UniversityLianjin Jin - Thomas Jefferson UniversityFederica Sotgia - Thomas Jefferson UniversityMichael P Lisanti - Sidney Kimmel Cancer CenterRichard G Pestell - Thomas Jefferson UniversityAdam P Dicker - Thomas Jefferson UniversityNicole L Simone - Thomas Jefferson University
- Publication Details
- The oncologist (Dayton, Ohio), v 18(1), pp 97-103
- Grant note
- P30 CA56036 / NCI NIH HHS P30 CA056036 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000314703200019
- Scopus ID
- 2-s2.0-84873037371
- Other Identifier
- 991021897279904721
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- Web of Science research areas
- Oncology