Journal article
Nutritional Supplementation in Monochorionic Diamniotic Twin Pregnancies: Impact on Twin-Twin Transfusion Syndrome
American journal of perinatology, v 25(10), pp 667-672
01 Nov 2008
PMID: 18942043
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Twin-to-twin transfusion syndrome (TTTS) has been related to unbalanced unidirectional arteriovenous anastomoses in the placenta of monochorionic diamniotic (DiMo) twin gestations. As maternal malnutrition accounting for hypoproteinemia and anemia has been detected in severe cases of TTTS, the purpose of this study was to evaluate the impact of early diet supplementation on TTTS. Fifty-one Dimo twin pregnancies were given commercially available oral nutritional diet supplements and then compared in a retrospective cohort study to 52 twin gestations with the same chorionicity but not subjected to nutritional supplementation. Diet supplementation was associated with lower overall incidence of TTTS (20/52 versus 8/51, p=0.02) and with lower prevalence of TTTS at delivery (18/52 versus 6/51, p=0.012) when compared with no supplementation. Nutritional intervention also significantly prolonged the time between the diagnosis of TTTS and delivery (9.4 +/- 3.7 weeks versus 4.6 +/- 6.5 weeks; p = 0.014). The earlier nutritional regimen was introduced, the lesser chance of detecting TTTS (p = 0.001). Although not statistically significant, dietary intervention was also associated with lower Quintero stage, fewer invasive treatments, and lower twin birth weight discordance. Diet supplementation appears to counter maternal metabolic abnormalities in DiMo twin pregnancies and improve perinatal outcomes in TTTS when combined with the standard therapeutic options.
Metrics
Details
- Title
- Nutritional Supplementation in Monochorionic Diamniotic Twin Pregnancies: Impact on Twin-Twin Transfusion Syndrome
- Creators
- Giuseppe Chiossi - Allegheny General HospitalMatthew R. Quigley - Allegheny General HospitalEmmanuel J. Esaka - Allegheny General HospitalKristin Novic - Allegheny General HospitalJennifer U. Celebrezze - Allegheny General HospitalSteven H. Golde - Allegheny General HospitalRonald L. Thomas - Allegheny General Hospital
- Publication Details
- American journal of perinatology, v 25(10), pp 667-672
- Publisher
- Thieme Medical Publishers
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery; Obstetrics and Gynecology
- Web of Science ID
- WOS:000261311500011
- Scopus ID
- 2-s2.0-57149092379
- Other Identifier
- 991021965358004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics