Journal article
O-021 : Nonalcoholic Fatty Liver Disease and Development of Chronic Kidney Disease: A Cohort Study
춘·추계 학술대회 (KASL), Vol.2017(1), p26
24 Jun 2017
Abstract
Aims: Nonalcoholic fatty liver disease (NAFLD) has been associated with chronic kidney disease (CKD), but cohort studies are limited. We investigated the longitudinal association of NAFLD and its severity with the development of CKD.
Methods: We performed a retrospective cohort study of 41,430 adult men and women (average age, 48.9 y) without CKD at baseline who underwent repeated health check-up examinations from January 1, 2003, through December 31, 2013. NAFLD status was assessed by ultrasonography, and NAFLD severity was assessed by the NAFLD fibrosis score (NFS).
Results: The outcome was an incident CKD, defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m 2 . During 200,790 person-years of follow-up (median 4.15 years), we identified 691 incident CKD cases. The multivariable-adjusted hazard ratio for CKD comparing participants with and without NAFLD was 1.22 (95% confidence interval [CI], 1.04-1.43). The risk of CKD increased progressively with increased NAFLD severity. The multivariable-adjusted hazard ratios for CKD comparing participants with NFS < -1.455 and those with NFS ≥ -1.455 to participants without NAFLD were 1.09 (0.91-1.32) and 1.58 (1.30-1.92), respectively. The association was consistent across clinically relevant subgroups.
Conclusions: In a large cohort of adult men and women without CKD, NAFLD was associated with an increased risk of CKD development. NAFLD may adversely affect renal function and may need careful attention for an increased risk of CKD.
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Details
- Title
- O-021 : Nonalcoholic Fatty Liver Disease and Development of Chronic Kidney Disease: A Cohort Study
- Creators
- Dong Hyun SinnDanbee KangHye Ryoun JangSeonhye GuSoo Jin ChoSeung Woon PaikSeungho RyuYoosoo ChangMariana LazoEliseo GuallarJuhee ChoGeum-youn Gwak
- Publication Details
- 춘·추계 학술대회 (KASL), Vol.2017(1), p26
- Publisher
- 대한간학회
- Number of pages
- 1
- Resource Type
- Journal article
- Language
- Korean
- Academic Unit
- Urban Health Collaborative
- Identifiers
- 991020550345404721