Journal article
O-029: Nonalcoholic Fatty Liver Disease and Progression of Coronary Artery Calcification: A Cohort Study
춘·추계 학술대회 (KASL), Vol.2016(1)
17 Jun 2016
Abstract
Aims: Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestationof the metabolic syndrome, was associated with subclinical atherosclerosis atherosclerosisin many crosssectional studies, but the prospective associationbetween NAFLD and the progression of atherosclerosis has not beenevaluated. This study was conducted to evaluate the association betweenNAFLD and the progression of coronary atherosclerosis.Methods: This cohort study included 4,731 adult men and womenwith no history of CVD, liver disease or cancer at baseline who participatedin a repeated regular health screening exam between 2004and 2013. Fatty liver was diagnosed by ultrasound based on standardcriteria, including parenchymal brightness, liver-to-kidney contrast,deep beam attenuation and bright vessel walls. Progression of coronaryartery calcium (CAC) scores was measured using multidetectorCT scanners.Results: The annual rate of CAC progression in participants with andwithout NAFLD were 22% (95% confidence interval 20 - 23%) and17% (16 - 18%), respectively (p<0.001). The multivariable ratio ofprogression rates comparing participants with NAFLD to those withoutNAFLD was 1.04 (1.02 - 1.05; p<0.001). The association betweenNAFLD and CAC progression was similar in most subgroups analyzed,including in participants with CAC 0 and in those with CAC > 0at baseline.Conclusions: In this large cohort study of adult men and womenwith no history of CVD, NAFLD was significantly associated with thedevelopment of CAC independently of cardiovascular and metabolicrisk factors. NAFLD may play a pathophysiologic role in atherosclerosisdevelopment and may be useful to identify subjects with a higherrisk of subclinical disease progression.
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Details
- Title
- O-029: Nonalcoholic Fatty Liver Disease and Progression of Coronary Artery Calcification: A Cohort Study
- Creators
- Dong Hyun SinnDanbee KangYoosoo ChangSeungho RyuSeonhye GuHyunkyoung KimDonghyeong SeongSoo Jin ChoByoung-kee YiHyung-doo ParkSeung Woon PaikYoung Bin SongMariana Lazo
- Publication Details
- 춘·추계 학술대회 (KASL), Vol.2016(1)
- Publisher
- 대한간학회
- Number of pages
- 1
- Resource Type
- Journal article
- Language
- Korean
- Academic Unit
- Urban Health Collaborative
- Identifiers
- 991020550494204721