Journal article
O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling
Journal of molecular biology, v 428(16), pp 3282-3294
14 Aug 2016
PMID: 27343361
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of β-D-N-acetylglucosamine sugars to nuclear and cytoplasmic proteins. Increased total O-GlcNAcylation is emerging as a general characteristic of cancer cells, and recent studies suggest that O-GlcNAcylation is a central communicator of nutritional status to control key signaling and metabolic pathways that regulate multiple cancer cell phenotypes. This review summarizes our current understanding of changes of O-GlcNAc cycling enzymes in cancer, the role of O-GlcNAcylation in tumorigenesis, and the current challenges in targeting this pathway therapeutically.
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Details
- Title
- O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling
- Creators
- Christina M Ferrer - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USAValerie L Sodi - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USAMauricio J Reginato - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. Electronic address: Mauricio.Reginato@drexelmed.edu
- Publication Details
- Journal of molecular biology, v 428(16), pp 3282-3294
- Publisher
- Elsevier; England
- Grant note
- F31 CA192868 / NCI NIH HHS F31 CA183574 / NCI NIH HHS R01 CA155413 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000382408900011
- Scopus ID
- 2-s2.0-84982062721
- Other Identifier
- 991014878111204721
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- Web of Science research areas
- Biochemistry & Molecular Biology