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O-GlcNAcylation: key regulator of glycolytic pathways
Journal article   Open access   Peer reviewed

O-GlcNAcylation: key regulator of glycolytic pathways

Zachary A Bacigalupa, Chaitali H Bhadiadra and Mauricio J Reginato
Journal of bioenergetics and biomembranes, v 50(3), pp 189-198
Jun 2018
PMID: 29344764
url
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386736View
Accepted (AM)Open Access (License Unspecified) Open

Abstract

Acetylglucosamine - metabolism Animals Glycolysis Glycosylation Humans Metabolic Networks and Pathways Nervous System - metabolism
Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current understanding of how O-GlcNAcylation regulates glycolytic pathways and contributes to alterations in cancer cell metabolism.

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38 citations in Scopus

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Web of Science research areas
Biophysics
Cell Biology
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