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Accepted (AM)Open Access (License Unspecified), Open
Journal article
O-GlcNAcylation regulation of cellular signaling in cancer
Cellular signalling, v 90, 110201
Feb 2022
PMID: 34800629
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
O-GlcNAcylation is a post-translational modification occurring on serine/threonine residues of nuclear and cytoplasmic proteins, mediated by the enzymes OGT and OGA which catalyze the addition or removal of the UDP-GlcNAc moieties, respectively. Structural changes brought by this modification lead to alternations of protein stability, protein-protein interactions, and phosphorylation. Importantly, O-GlcNAcylation is a nutrient sensor by coupling nutrient sensing with cellular signaling. Elevated levels of OGT and O-GlcNAc have been reported in a variety of cancers and has been linked to regulation of multiple cancer signaling pathways. In this review, we discuss the most recent findings on the role of O-GlcNAcylation as a metabolic sensor in signaling pathways and immune response in cancer.
•The post-translational modification O-GlcNAcylation is found to be elevated in nearly all cancers.•This nutrient sensitive intracellular glycosylation can regulate a diverse set of cytosolic and nuclear proteins.•O-GlcNAcylation regulates signaling pathways including transcription, metabolic and immune regulation in cancer cells.•This review highlight most recent understanding of mechanisms by which O-GlcNAcylation regulates cancer cell signaling.
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Details
- Title
- O-GlcNAcylation regulation of cellular signaling in cancer
- Creators
- Lorela Ciraku - Drexel UniversityEmily M. Esquea - Drexel UniversityMauricio J. Reginato - Thomas Jefferson University
- Publication Details
- Cellular signalling, v 90, 110201
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000729448200009
- Scopus ID
- 2-s2.0-85119995829
- Other Identifier
- 991019168765704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology