Journal article
O sub(2)-Hb reaction kinetics and the Fahraeus effect during stagnant, hypoxic, and anemic supply deficit
Annals of biomedical engineering, Vol.26(1)
01 Feb 1998
Abstract
We modified our previous computer model of O sub(2) and CO sub(2) transport in the cerebral microcirculation to include nonequilibrium O sub(2)-Hb kinetics and the Fahraeus effect (reduced tube hematocrit in small microvessels). The model is a steady-state multicompartmental simulation which includes three arteriolar compartments, three venular compartments, and one capillary compartment. Three different types of oxygen deficits (stagnant, hypoxic, and anemic conditions) were simulated by respectively reducing blood flow, arterial O sub(2) saturation, and systemic hematocrit to one half of normal. Microcirculatory distributions for P sub(O(2)), P sub(CO(2)), O sub(2) saturation and deviations from equilibrium, and the O sub(2) and CO sub(2) fluxes for each compartment were predicted for the three O sub(2) supply deficits. Differences were found for O sub(2) extraction ratios and relative contributions of arteriolar, venular, and capillary gas fluxes for each type of deficit. The Fahraeus effect and O sub(2)-Hb kinetics reduced O sub(2) extraction in all cases and altered microcirculatory gas distributions depending on the specific type of O sub(2) supply deficits. The modified model continues to predict that capillaries are the major site where gas exchange takes place, and demonstrates that the Fahraeus effect and nonequilibrium O sub(2)-Hb kinetics are important mechanisms that should not be neglected in O sub(2) and CO sub(2) transport modeling. While this model provides useful insight regarding the influence of the Fahraeus effect and O sub(2)-Hb kinetics under steady state, the addition of a distributed and dynamic simulation should further elucidate the effects of the brain's heterogeneous properties and transient behavior.
Metrics
1 Record Views
Details
- Title
- O sub(2)-Hb reaction kinetics and the Fahraeus effect during stagnant, hypoxic, and anemic supply deficit
- Creators
- Guo-Fan YeDov JaronDonald BuerkMin-Chih ChouWenyao Shi
- Publication Details
- Annals of biomedical engineering, Vol.26(1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]; Drexel University
- Identifiers
- 991019341957304721